Epigenetic Regulation of Mammary Epithelial Differentiation and Lineage Plasticity.

Skibinski, Adam.

2014

Description
  • Abstract: Lineage-committed cells of many tissues exhibit substantial plasticity in contexts such as wound healing and tumorigenesis, but the regulation of this process is not well understood. Here, I studied the molecular mechanisms that either allow mammary epithelial cells (MECs) to transdifferentiate or dedifferentiate in specific contexts. I identified the Hippo transducer WWTR1/TAZ in a scre... read more
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