The Role of Chromatin Remodeling Enzymes in Prevention of CAG-Repeat Expansions.

Walsh, Stephen C.


  • Expansions of CAG repeats, often caused by errors in DNA replication, repair, and recombination, can cause neurodegenerative diseases. However, organisms can employ a number of strategies in preventing genomic instability. Previous data in our lab suggests that acetylation of lysine residues H4-K12 and H4-K16 at CAG repeats is important in marking the DNA for repair, but the exact molecular mechan... read more
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