Silk Electrogel Based Gastroretentive Drug Delivery System.
cancer has become a global pandemic and there is imperative to develop efficient
therapies. Oral dosing strategy is the preferred route to deliver drugs for treating the
disease. Recent studies suggested silk electro hydrogel, which is pH sensitive and
reversible, has potential as a vehicle to deliver the drug in the stomach environment.
The aim of this study is to establish ... read morein vitro electrogelation e-gel based silk gel as a
gastroretentive drug delivery system. We successfully extended the duration of silk
e-gel in artificial gastric juice by mixing silk solution with glycerol at different
ratios before the electrogelation. Structural analysis indicated the extended duration
was due to the change of beta sheet content. The glycerol mixed silk e-gel had good
doxorubicin loading capability and could release doxorubicin in a sustained-release
profile. Doxorubicin loaded silk e-gels were applied to human gastric cancer cells.
Significant cell viability decrease was observed. We believe that with further
characterization as well as functional analysis, the silk e-gel system has the potential
to become an effective vehicle for gastric drug delivery
Thesis (M.S.)--Tufts University, 2015.
Submitted to the Dept. of Biomedical Engineering.
Advisor: David Kaplan.
Committee: Qiaobing Xu, and Kyongbum Lee.
Keywords: Materials Science, and Biomedical engineering.read less