Legionella pneumophila and the Host Endoplasmic Reticulum: How a Single Bacterial Protein Catalyzes a Novel Multi-Step Ubiquitination Pathway to Manipulate Tubular ER

Kotewicz, Kristin.


  • Abstract: Intracellular pathogens manipulate host organelles to support replication within cells. In the case of Legionella pneumophila, the bacterium translocates proteins that establish an endoplasmic reticulum (ER)-associated replication compartment. Using high-resolution electron microscopy and fluorescence microscopy we show that the bacterial Sde proteins target host reticulon 4 (Rtn4) to co... read more
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