Impact of Retinoblastoma Protein Loss on Osteoblast Migration and Differentiation.

Gunduz, Volkan.


  • Abstract: The retinoblastoma protein pathway is inactivated in a wide range of human cancers. RB1 itself, however, is frequently inactivated only in a subset of tumors including retinoblastoma and osteosarcoma (OS). The fact that RB1 loss favors tumor formation in certain tissues suggests that pRB might have tissue-specific functions in addition to its central role in cell cycle regulation. Indeed... read more
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