The endosomal-associated deubiquitinating enzyme USP8 regulates BACE1 ubiquitination and degradation.

Yeates, Eniola.


  • Abstract: -site amyloid precursor protein cleaving enzyme (BACE1) is the rate-limiting enzyme in the production of amyloid beta (A), the toxic peptide that accumulates in the brain of subjects affected by Alzheimer's disease. Previous studies have shown that BACE1 is degraded via the lysosomal pathway, BACE1 is ubiquitinated at lysine 501 and that blocking ubiquitination at lysine 501 results in B... read more
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