Background: The intravenous use of polymyxins has been considered to be
associated with considerable nephrotoxicity and neurotoxicity. For this reason, the
systemic administration of polymyxins had been abandoned for about 20 years in most
areas of the world. However, the problem of infections due to multidrug-resistant
(MDR) Gram-negative ... read morebacteria such us Pseudomonas aeruginosa and Acinetobacter
baumanniii has led to the re-use of polymyxins. Our objective was to study the
toxicity of prolonged intravenous administration of colistin (polymyxin
E).
Falagas, Matthew, Michael Rizos, Ioannis A. Bliziotis, Kostas
Rellos, Sofia K. Kasiakou, and Argyris Michalopoulos. "Toxicity after prolonged (more
than four weeks) administration of intravenous colistin." BMC Infectious Diseases 5,
no. 1 (12, 2005): 1-8.