| Description |
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Background: In the last decade, network meta-analysis of randomized
controlled trials has been introduced as an extension of pairwise meta-analysis. The
advantage of network meta-analysis over standard pairwise meta-analysis is that it
facilitates indirect comparisons of multiple interventions that have not been studied
in a head-to-head ... read morefashion. Although assumptions underlying pairwise meta-analyses are
well understood, those concerning network meta-analyses are perceived to be more
complex and prone to misinterpretation.
Keywords: Bias, Comparative effectiveness, Confounding, Effect
modification, Indirect comparison, Meta-analysis, Mixed treatment comparison, Network
meta-analysis, Randomized controlled trial, Systematic review.
Springer Open.read less
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