A model system to study contractions of the (GAA)n repeats in yeast Saccharomyces cerevisiae

Shimberg, William Reed

2012

Description
  • DNA naturally contains many repetitive sequences some of which are dinucleotide, trinucleotide, pentanucleotide and dodecanucleotide repeats. Some repetitive sequences can form unusual structures in the DNA, which can interfere with replication, transcription, and repair processes and cause instability of the DNA. This instability can be detected as expansions or contractions in the length of the ... read more
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