Regulated Assembly of the V-ATPase: Structural Insights, Physiological Function, and Control by Cellular Signaling Pathways.

Liberman, Rachel.


  • Abstract: The vacuolar (H+)-ATPases (V-ATPases) are ATP-driven proton pumps composed of a peripheral V1 domain and a membrane embedded V0 domain. Regulated assembly of V1 and V0 represents an important regulatory mechanism for controlling V-ATPase activity in vivo. This thesis investigates regulated assembly using both yeast as a model system and dendritic cells, where V-ATPase activity is im... read more
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