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Background: Although recent progress has been made in treating
castration resistant prostate cancer, the interplay of signaling pathways which
enable castration resistant growth is incompletely understood. A data driven,
multivariate approach, was used in this study to predict prostate cancer cell
survival based on the phosphorylation ... read morelevels of key proteins in PC3, LNCaP, and
MDA-PCa-2b cell lines in response to EGF, IGF1, IL6, TNFα, dihydrotestosterone, and
docetaxel treatment.
Keywords: Prostate cancer, Phosphoproteome, Castration resistance,
Regression analysis, Cell signaling.
Springer Open.read less
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