Identification of Loop Mediated Protein-Protein Interactions and Design of Cyclic Peptide Locked Loop Inhibitors

Siegert, Timothy.


  • Abstract: The landscape of drug discovery has recently begun to shift from traditionally druggable enzymes to protein-protein interactions (PPIs). Enzymes possess well defined active sites, while PPIs often have large and flat surface areas that small molecules can not interrupt. As this landscape shifts, it is essential that the tools used to target these proteins change to meet these demands. ... read more
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