%0 PDF %T The VieB auxiliary protein negatively regulates the VieSA signal transduction system in Vibrio cholerae. %A Mitchell, Stephanie L.; Ismail, Ayman M.; Kenrick, Sophia A.; Camilli, Andrew. %D 2016-08-16T18:21:26.883Z %8 2016-08-16 %R http://localhost/files/73666h19r %X Background: Vibrio cholerae is a facultative pathogen that lives in the aquatic environment and the human host. The ability of V. cholerae to monitor environmental changes as it transitions between these diverse environments is vital to its pathogenic lifestyle. One way V. cholerae senses changing external stimuli is through the three-component signal transduction system, VieSAB, which is encoded by the vieSAB operon. The VieSAB system plays a role in the inverse regulation of biofilm and virulence genes by controlling the concentration of the secondary messenger, cyclic-di-GMP. While the sensor kinase, VieS, and the response regulator, VieA, behave similar to typical two-component phosphorelay systems, the role of the auxiliary protein, VieB, is unclear.; Keywords: Two-component system, Phosphorelay, Bacterial signal transduction, Protein phosphorylation, Phosphodiesterases, Tetratricopeptide repeat domain, Vibrio cholerae.; Springer Open. %[ 2018-10-11 %9 Text %~ Tufts Digital Library %W Institution