Pharmacological Boosting Effect and Inhibitory Mechanism of Cobicistat and Ritonavir on Human Cytochrome P450 Isoforms.

Tran, Timothy.


  • Abstract: Abstract Pharmacokinetic boosting is the result of one drug increasing another co-administered drug's serum concentration to achieve a therapeutic effect. Here in this study, two protease inhibitor (PI) class drugs used in treatment of HIV that have boosting effects are evaluated for their potency and mechanism of inhibition on cytochrome P450 isoforms. Ritonavir is a widely used ... read more
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