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Abstract: Adult and
postnatal tendons heal poorly, forming scar tissue with aberrant properties. In
contrast, embryonic tendons heal in a scarless manner, with restoration of native tissue
properties. Investigation of scarless embryonic tendon healing may lead to strategies
for improving adult tendon healing. We probed differences in embryonic and postnatal
tendon cell responses to wound-related ... read moreenvironmental factors, as well as potential
mechanisms that may regulate their respective responses. Factors we tested included
IL-1beta treatment, substrate elastic modulus, and extracellular matrix composition. We
found that postnatal tendon cells have higher expression of inflammatory mediators and
matrix metalloproteinases than embryonic tendon cells, both at baseline and in response
to IL-1beta treatment, and that this disparity may be due to differences in IL-1
receptor profiles. The long-term goal of this project is to develop strategies to
redirect adult scarred tendon healing outcomes toward more embryonic-like scarless
tissue regeneration.
Thesis (M.S.)--Tufts
University, 2015.
Submitted to the Dept. of
Biomedical Engineering.
Advisor: Catherine
Kuo.
Committee: David Kaplan, and Li
Zeng.
Keyword: Biomedical
engineering.read less
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