Paper-based Analytical Devices with Integrated VLSI Potentiostat
Abstract: There is a
need for low cost, self-contained, point-of-care medical diagnostics for resource poor
settings. Such diagnostics have the potential to greatly improve health outcomes through
early detection and rapid diagnosis. Recently, paper based devices similar to paper
strips in glucose meters have been demonstrated as a viable and low cost platform for
diagnostics. In addition to ... read morebeing low cost, paper is easily transportable, biocompatible
and can be safely disposed by incineration. Furthermore these paper-based sensors can be
fabricated at room temperature using readily available and inexpensive equipment and
materials, essential in regions with limited resources. Paper based devices which employ
electrochemical sensing methods are the most sensitive class of these devices.
Unfortunately, readout is traditionally completed with a benchtop potentiostat not
suitable for portable applications. This thesis presents a CMOS readout IC with a VLSI
potentiostat designed for sensing with paper-based electrochemical biosensors and a 3D
electrochemical paper based analytical device suitable for multi-analyte detection. The
platform is evaluated for dopamine and glucose sensing. Collectively, this work
contributes to a portable low-cost diagnostics platform for use in resource scarce
Thesis (M.S.)--Tufts University, 2016.
Submitted to the Dept. of Electrical Engineering.
Advisor: Sameer Sonkusale.
Committee: Valencia Koomson, and Xiaocheng Jiang.
Keyword: Electrical engineering.read less