Elucidating the multiple functions of POLDIP2 in Drosophila melanogaster.

Castaneda, Juan.


  • We are interested in the potential role POLDIP2 might play regarding polymerase recruitment and switching during DNA repair in Drosophila melanogaster. Complete deletion of the gene was induced via the CRISPR Cas-9 editing system and a DsRed marker was inserted into the POLDIP2 locus via homology-directed repair. Intriguingly, flies homozygous for the deletion incur lethality at the second-instar ... read more
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