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Abstract: Interactions
of natural products with prescription drugs have become an issue of medical and public
health concern. Blueberry juice at low concentrations produces inhibition of cytochrome
P450 (CYP) 3A activity in vitro1. As the pharmacologically active constituents in
blueberry juice, anthocyanin and phenolic reveal inhibit effect on CYP3A. Of 4
anthocyanin derivatives and 3 phenol... read moreic compounds were measured as potential inhibitor in
screen inhibition test, result showed that Malvidin-3-glucoside, Peonidin-3-glucoside,
Delphinidin-3-glucoside, Cyanidin-3-glucoside and Quercetin inhibited examined human
microsome in a concentration-dependent manner featuring IC50 values from 8.8uM up to
89.2uM. To better understand the absorption and pharmacokinetic profile of blueberry
anthocyanin and phenolic after consumed by human, a clinical study was involved. In
human study, 12 healthy volunteers were required to take either water (300ml) or 50:50
mixture of lowbush and highbush blueberry juice (300ml) twice a day, and the blood
samples were drawing during 12h after index substrate administration. Here, proteins
remove, liquid-liquid extraction, high-performance liquid chromatography and mass
spectrometry techniques are described for isolation, separation and identification of
anthocyanin and phenolic in human plasma.
Thesis
(M.S.)--Tufts University, 2018.
Submitted to the
Dept. of Pharmacology and Drug Development.
Advisor:
David Greenblatt.
Keyword:
Pharmacology.read less
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