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Abstract: Psychophysiological and neuroimaging research has demonstrated impaired fear conditioning responses in PTSD. However, the origin of these biological abnormalities has not yet been identified. The purpose of this study was to determine whether these psychophysiological and neural abnormalities in PTSD are familial vulnerability factors, effects of trauma exposure, or are acquired ... read morecharacteristics of PTSD. In this case-control twin study, monozygotic twin pairs discordant for combat exposure completed a fear conditioning and extinction paradigm. Skin conductance responses (SCR) and brain activation during the task were measured. Results indicate that a decreased ability to distinguish between safety and threat cues, as indicated by SCR, and increased activation in the left and right insula during early trials of conditioning may be familial vulnerability factors of PTSD. The origin of these abnormalities has potential clinical implications for primary and/or secondary prevention of PTSD.
Thesis (M.S.)--Tufts University, 2018.
Submitted to the Dept. of Psychology.
Advisor: Lisa Shin.
Committee: Joseph DeBold, and Marie-France Marin.
Keywords: Clinical psychology, Cognitive psychology, and Behavioral sciences.read less
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