Multiple roles for corticotropin releasing factor: acute and enduring effects of CRF on cocaine self-administration via interactions with mesolimbic circuitry.

Leonard, Michael.


  • Addiction can be characterized as a disorder of aberrant drug- or reward-seeking behavior. This pattern of behavior emerges, in part, from a dysfunction in how we perceive and anticipate the rewarding consequences of drug-associated contexts or cues. It is well known that stress experience contributes to addiction vulnerability, perhaps due to its profound effects on motivated behavior. The ability ... read more
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