Cholera Case Control Studies: A Systematic Review and Analysis
Abstract: Cholera is
an acute, diarrheal disease caused by Vibrio cholerae serogroup O1 or O139. Ingestion of
fecally contaminated food and water causes the disease. Various exposures can lead to
ingestion of contaminated food and water. A systematic review was performed to determine
the exposures associated with cholera. Existing literature on cholera case control
studies was examined for th... read moree following exposures: (1) Water supply, (2) Water Storage,
(3) Water Treatment, (4) Sanitation, (5) Hygiene, (6) Knowledge of cholera prevention,
(7) Food, (8) Socioeconomic status, and (9) Other. Exposures that were predicted risk
factors were all, as expected, significantly associated with cholera outcome. Exposures
predicted as protective were, as expected, protective against the disease but were not
significant across all contexts. The results from this review explain exposures
associated with cholera in different contexts and are expected to guide policy towards
implementing context driven protective factors
Thesis (M.S.)--Tufts University, 2016.
Submitted to the Dept. of Civil Engineering.
Advisor: Daniele Lantagne.
Committee: Mark Woodin, David Gute, and Travis Yates.
Keyword: Environmental health.read less