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Autophagy is a cellular degradation pathway which recycles cytosolic material into energy and biomolecules that fuel cell function. Autophagy dysregulation characterizes many pathologies, and the development of autophagy inhibitors presents a promising avenue for cancer therapeutics and general autophagy research. In this project, a library of selective autophagy inhibitors targeting the ... read moreautophagy-associated proteins LC3/GABARAPs was affinity profiled in binding assays across the six paralogs of LC3/GABARAPs in the human genome in order to elucidate inhibitor specificity, potency, and binding mode.
Thesis (B.S.)--Tufts University, 2022.
Submitted to the Dept. of Biology.
Committee: Benjamin Wolfe, Charles Mace, and Joshua Kritzer.read less
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