Immunoprofiling Lymphocyte Subsets Implicated in the Pathogenesis of Ankylosing Spondylitis: A Comparison with HLA-B27-Genotyped Controls

Lawicki, Jake R.


  • A significant association exists between Ankylosing Spondylitis (AS) and HLA-B27, an allelic variant of the HLA-B gene encoding the heavy chain of the Major Histocompatibility Complex, Class I (MHC-I) protein complex. Killer Immunoglobulin-Like Receptors (KIRs) are polymorphic receptors that bind to canonical and variant MHC-I complexes. KIRs modulate Natural Killer cell function, but are also ... read more
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