Activation of membrane progesterone receptors mediates the metabotropic effects of neurosteroids on GABAAR phosphorylation and tonic inhibition

Parakala, Manasa.


  • Abstract: Neurosteroids have been well characterized as positive allosteric modulators of the GABAAR. However, previous studies in our lab have identified an additional role for neurosteroids in mediating phosphorylation and stability of α4-containing GABAARs. In this body of work, I show through both biochemical and electrophysiological methods that this novel role is (1) not specific to the ... read more
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