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Abstract: According to contemporary epidemiological and experimental
evidence, we propose a novel classification of cancers based on pathogenesis instead
of classifications based on histological appearance of cancer. This new scheme first
defines cancers as either 1. inborn errors of development or 2. sporadic ones, and
then sub-defines ... read morethe former into 1A. inborn inherited errors of development, being
those due to mutations contributed by one or both parents' gametes to the developing
conceptus, and 1B. inborn induced errors of development when the malformations and/or
cancers are due to environmental carcinogenic exposure during pregnancy. It is
anticipated that the origin of an increasing number of so-called sporadic cancers
will turn out to be linked to the inborn induced errors of development
group.
Keywords: Carcinogenesis, Pathobiology, Metastasis, Neoplasia, Mutation,
Tissue organization field, Cancer theories.
Springer Open.read less
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