The Role of D-loop Synthesis and Progression in Trinucleotide Repeat Instability Through a Break-induced Replication (BIR) Model

Sanders, Emma A.


  • Homologous recombination is a complex, multi-step process, that has been linked to increasing instability of trinucleotide repeats in Saccharomyces cerevisiae. Due to the involvement of a variety of polymerases and accessory factors during D-loop synthesis and progression, we hypothesize that at this stage there is a high risk of slippage and stalling which could lead to instability of a trinucleotide ... read more
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