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Rad5 is a protein that has been shown to impact recombination-mediated repair at CAG repeats. Interestingly, Rad5 is part of a larger family of proteins which are characterized by a SWI/SNF2 helicase motif interrupted by a RING finger domain, thus conferring chromatin remodeling capability. We show that Rad5, Irc20, Uls1, and Rad16 have significant roles in preventing CAG repeat fragility together ... read moreand that Irc20 may have a compensatory relationship with Rad5 in certain model systems. Advisor: Dr. Catherine Freudenreich.read less
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