Developing peptide inhibitors of Shp2 through a one-bead-one-compound approach.

Tomlinson, Kira Leigh.

2017

Description
  • Shp2 is a protein tyrosine phosphatase that is mutated in Noonan syndrome and myeloid neoplasms, and aberrantly activated in HER-positive breast cancers and H. pylori-induced gastric cancer. Shp2 has been found to act upstream of a variety of growth factor and cytokine signaling pathways, but its role within the cell has not been fully elucidated. Potent and specific inhibitors of Shp2 are needed ... read more
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