Metabolic Engineering for the Heterologous Biosynthesis of Erythromycin A and Associated Polyketide Products in Escherichia coli.

Zhang, Haoran.


  • Abstract: The natural product erythromycin is a potent and widely used antibiotic for bacterial infections. In structure, erythromycin consists of one 14-membered polyketide ring, 6-deoxy-erythronolide B (6dEB), and two sugar residues, cladinose and desosamine. Erythromycin is natively produced by a soil-dwelling bacterium Saccharopolyspora erythraea that is fastidious in its growth requirements a... read more
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