Synthesis-Dependent Microhomology-Mediated End Joining: A Unifying Model For Multiple DNA Double Strand Break Repair Outcomes.

Yu, Amy.


  • Abstract: DNA double-strand breaks (DSBs) are repaired by homology-directed repair or non-homologous end joining. End-joining repair can be classified as classical non-homologous end joining, which requires DNA ligase 4, or "alternative" end joining (alt-EJ), which does not. The mechanism of alt-EJ is largely uncharacterized. We show that Drosophila melanogaster DNA polymerase theta (pol theta), e... read more
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