Molecular Design of Therapeutics for the Treatment of Type II Diabetes and Cardiovascular Disease.

Du, Jasper L.

2017

Description
  • Glucose-dependent insulinotropic peptide (GIP) is a 31-amino acid peptide hormone that is secreted by K-cells to regulate postprandial glucose levels. By binding to its receptor, GIPR, GIP mediates several beneficial effects such as improved insulin sensitivity, increased β-cell mass, and increased energy consumption. However, dipeptidyl peptidase-4 (DPP-4) rapidly inactivates GIP, within 5-7 min.... read more
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