"An In-Vitro Approach to Identifying Potential Drug Candidates to Prevent Acetaminophen Toxicity"

Youngblood, Vaughn.


  • Abstract: Abstract Hepatic toxicity due to acetaminophen (APAP) is the leading cause of acute liver failure in the United States. Acetaminophen is largely metabolized by sulfotransferases and glucuronyl transferases. Once these enzymes are saturated, APAP is metabolized by CYP450 enzymes, particularly CYP2E1, into a hepatotoxic metabolite called N-acetyl- ρ-benzoquinone imine (NAPQI). Quantitative... read more
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