Roles of RIPK1/RIPK3 homo- and hetero-dimerization in cell death and pro-inflammatory signaling

Yang, Xuzhong.


  • Abstract: Necroptosis, a form of regulated necrosis, has been reported to be involved in numerous inflammatory diseases including multiple sclerosis, ischemia reperfusion injury, atherosclerosis, inflammatory bowel syndrome, and pancreatitis. Two homologous Ser/Thr kinases, receptor-interacting protein 1 (RIPK1) and RIPK3, play an important role in mediating necroptosis. RIPK1 and RIPk3 form heter... read more
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