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To fill a demand for synthetic oligosaccharides for biochemical study, new methods of synthesis must fill standard in both purity and efficiency. Eliminating the need for chromatography purification during synthesis lessens the manual work needed to synthesize each sequence and allows a greater degree of automation. This thesis describes a new cap-and tag solid phase oligosaccharide synthesis. ... read moreCompleted sequences were tagged with an alkyne linker-tag and captured onto azide functionalized catch resin using 'click' chemistry. Filtration separated these desired sequences from incomplete 'truncated' sequences. A mannose monomer and a trimannose sequence were synthesized on the solid phase to demonstrate proof of concept. This method allows synthesis of oligosaccharides without the use of chromatography and is designed for ease with automated parallel synthesis.read less
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