Optimizing fPET-FDG.
Morin, Thomas M.
2017
- Recent work by Villien, et al. presented the development of a new functional brain imaging method known as fPET-FDG (2014). With this method, it is possible to observe repeated task-specific changes in cerebral glucose metabolism during a single dynamic PET scan. Previously, the method has been limited to detecting these changes only at late time-points, 20-30 minutes after the start of a scan.We ... read morehypothesized that with an improved protocol for the administration of the 2-[18F]-fluoro-deoxyglucose (FDG) radiotracer, we could detect task-specific changes in FDG signal at earlier time points than was previously possible. Simulations suggested that in order to detect these changes, we would require a specialized general linear model (GLM), different from that used in previous fPET-FDG studies. Using the new GLM, our study demonstrated the successful detection of these task-specific signal changes at early time points in one subject. Further work is needed to validate this model and to replicate it in other subjects.Future optimization of the fPET-FDG methodology could allow us to examine dynamic changes in glucose metabolism associated with working memory, attention, and other areas of cognition. The fPET-FDG method could be especially useful in detecting real-time task-specific metabolic changes associated with various diseases such as diabetes.read less
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