Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial.

Liu, Zuyun.

Hsu, Fang-Chi.

Trombetti, Andrea.

King, Abby C.

Liu, Christine K.

Manini, Todd M.

Fielding, Roger A.

Pahor, Marco.

Newman, Anne B.

Kritchevsky, Stephen.

Gill, Thomas M.

2018

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  • Background: Whether physical activity can reduce cognitive frailty—a relatively new "compound" phenotype proposed in 2013—and whether the effect of physical activity differs based on levels of inflammation are unknown. Therefore, this study aimed to evaluate the effect of physical activity on cognitive frailty and whether baseline interleukin-6 (IL-6) levels modified this effect.

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