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Background: The presence of smaller low-density lipoproteins (LDL) has
been associated with atherosclerosis risk, and the insulin resistance (IR) underlying
the metabolic syndrome (MetS). In addition, some research has supported the
association of very low-, low- and high-density lipoprotein (VLDL HDL) particle
diameters with components ... read moreof the metabolic syndrome (MetS), although this has been
the focus of less research. We aimed to explore the relationship of VLDL, LDL and HDL
diameters to MetS and its features, and by clustering individuals by their diameters
of VLDL, LDL and HDL particles, to capture information across all three fractions of
lipoprotein into a unified phenotype.
Keywords: lipoprotein particle diameter, insulin resistance, nuclear
resonance spectroscopy, Metabolic Syndrome, latent class analysis, GOLDN, waist
circumference, hypertension, hypertriglyceridemia, fasting glucose.
Springer Open.read less
- Frazier-Wood, Alexis, Stephen Glasser, W. Timothy Garvey,
Edmond K. Kabagambe, Ingrid B. Borecki, Hemant K. Tiwari, Michael Y. Tsai, Paul N.
Hopkins, Jose M. Ordovas, and Donna K. Arnett. "A clustering analysis of lipoprotein
diameters in the metabolic syndrome." Lipids in Health and Disease 10, no. 1 (12,