Background: The presence of smaller low-density lipoproteins (LDL) has
been associated with atherosclerosis risk, and the insulin resistance (IR) underlying
the metabolic syndrome (MetS). In addition, some research has supported the
association of very low-, low- and high-density lipoprotein (VLDL HDL) particle
diameters with components o... read moref the metabolic syndrome (MetS), although this has been
the focus of less research. We aimed to explore the relationship of VLDL, LDL and HDL
diameters to MetS and its features, and by clustering individuals by their diameters
of VLDL, LDL and HDL particles, to capture information across all three fractions of
lipoprotein into a unified phenotype.
Frazier-Wood, Alexis, Stephen Glasser, W. Timothy Garvey,
Edmond K. Kabagambe, Ingrid B. Borecki, Hemant K. Tiwari, Michael Y. Tsai, Paul N.
Hopkins, Jose M. Ordovas, and Donna K. Arnett. "A clustering analysis of lipoprotein
diameters in the metabolic syndrome." Lipids in Health and Disease 10, no. 1 (12,