The regulation of interferon signaling and ER stress response by different Akt isoforms.

Ezell, Scott.


  • Abstract: The protein kinases Akt1, Akt2, and Akt3 possess non-redundant signaling properties, few of which have been investigated. Here we present evidence for an Akt1-dependent pathway that controls interferon-regulated gene expression and antiviral immunity. The target of this pathway is EMSY, an oncogenic interacting partner of BRCA2 that functions as a transcriptional repressor. Overexpressio... read more
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