Discovery of small molecule inhibitors of Immunoglobulin A1 proteases

Choudary, Santosh.


  • Abstract: Antibiotic-resistant bacteria are a major threat to global health, and will be for the foreseeable future. Inhibition of bacterial virulence factors is a promising alternative approach to treating bacterial infections, including infections caused by antibiotic resistant bacteria. Immunoglobulin A1 protease (IgA1P) is a virulence factor of a diverse group of Gram-negative and Gram-positiv... read more
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