Building Tools to Identify Interacting Partners of Rev1 Polymerase in its Novel Role in DNA Damage Tolerance by Template Switching.

Tomarchio, Gina M.


  • DNA replication is a dynamic and tightly regulated cellular process involving a complex cast of players but when the replication machinery encounters lesions or physical blockages in the DNA template, there is a threat to the integrity of the replication forks. If these lesions are not bypassed, replication forks will stall and eventually collapse and thus cells have evolved a set of mechanisms fo... read more
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