Development and Analysis of Synthetic Composite Materials Emulating Patient AAA Wall Material Properties.
Aortic Aneurysm (AAA) rupture accounts for 14,000 deaths a year in the United States.
Since the number of ruptures has not decreased significantly in recent years despite
improvements in imaging and surgical procedures, there is a need for an accurate,
noninvasive technique capable of establishing rupture risk for specific patients and
discriminating lesions at high risk. ... read moreIn this project, synthetic composite materials
replicating patient-specific wall stiffness and strength were developed and their
material properties evaluated. Composites utilizing various fibers were developed to
give a range of stiffness from 1825.75 kPa up through 8187.64 kPa with one base
material, Sylgard 170. A range of strength from 631.12 kPa to 1083 kPa with the same
base material was also found. By evaluating various base materials and various
reinforcing fibers, a catalogue of stiffnesses and strengths was started to allow for
adaptation to specific patient properties. Three specific patient properties were
well-matched with two composites fabricated: silk thread-reinforced Sylgard 170 and silk
thread-reinforced Dragon Skin 20. The composites showed similar stiffnesses to the
specific patients while reaching target stresses at particular strains. Not all patients
were matched with composites as of yet, but recommendations for future matches are able
to be determined. These composites will allow for the future evaluation of flow-induced
wall stresses in models replicating patient material properties and
Thesis (M.S.)--Tufts University, 2013.
Submitted to the Dept. of Biomedical Engineering.
Advisor: Robert Peattie.
Committee: David Kaplan, and Luis Dorfmann.
Keyword: Biomedical engineering.read less