The Role of Protease Activated Receptor 2 (PAR2) in the Development of Metabolically Induced Liver Pathology and Fibro-Inflammatory Processes

Shearer, Andrew.


  • Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) are related liver pathologies whose prevalence has increased in recent decades due to over nutrition and widespread adoption of a sedentary lifestyle. Protease-activated receptor-2 (PAR2) is a member of the PAR-family of G protein coupled receptors that are activated by extracellular serine proteases. This thesis ... read more
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