| Description |
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Background: Neuronal differentiation is largely under the control of
basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key roles
during development of the embryonic nervous system. In addition to well-characterised
regulation of their expression, increasing evidence is emerging for additional
post-translational ... read moreregulation of proneural protein activity. Of particular interest
is the bHLH proneural factor Neurogenin2 (Ngn2), which orchestrates progression from
neural progenitor to differentiated neuron in several regions of the central nervous
system. Previous studies have demonstrated a key role for cell cycle-dependent
multi-site phosphorylation of Ngn2 protein at Serine-Proline (SP) sites for
regulation of its neuronal differentiation activity, although the potential
structural and functional consequences of phosphorylation at different regions of the
protein are unclear.
Keywords: Phosphorylation, Intrinsic disorder, Protein NMR, Xenopus
laevis, Neurogenin, Protein stability, Transcription factor, bHLH proteins, Protein
folding.
Springer Open.read less
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This object is in collection
| Citation |
- McDowell, Gary, Christopher J. Hindley, Guy Lippens, Isabelle
Landrieu, and Anna Philpott. "Phosphorylation in intrinsically disordered regions
regulates the activity of Neurogenin2." BMC Biochemistry 15, no. 1 (12, 2014):
1-14.
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