Introduction: Normal and neoplastic breast tissues are comprised of
heterogeneous populations of epithelial cells exhibiting various degrees of
maturation and differentiation. While cultured cell lines have been derived from both
normal and malignant tissues, it remains unclear to what extent they retain similar
levels of differentiation ... read moreand heterogeneity as that found within breast
Keywords: allophycocyanin, cytokeratin, calf serum,
4',6-diamidino-2-phenylindole, ductal carcinoma in situ, Dulbecco's modified Eagle's
medium, epithelial to mesenchymal transition, epithelial cell adhesion molecule,
estrogen receptor, Ham's F12 medium, fluorescence activated cell sorting, flow
buffer, fetal bovine serum, fluorescein isothiocyanate, human epidermal growth
factor, human mammary epithelial, human breast epithelial cell, human telomerase,
mammary epithelial basal medium, mammary epithelial growth medium, phosphate buffered
saline, phycoerythrin, progesterone receptor, Roswell Park Memorial Institute-1640
medium, smooth muscle actin.
Keller, Patricia, Amy F. Lin, Lisa M. Arendt, Ina Klebba,
Ainsley D. Jones, Jenny A. Rudnick, Theresa A. DiMeo, Hannah Gilmore, Douglas M.
Jefferson, Roger A. Graham, Stephen P. Naber, Stuart Schnitt, and Charlotte
Kuperwasser. "Mapping the cellular and molecular heterogeneity of normal and
malignant breast tissues and cultured cell lines." Breast Cancer Research 12, no. 6
(10, 2010): 1-17.