Exploring Functional Differences Between Lipidated and Soluble Peptide Modulators of CMKLR1.

Heller, Daniel.

2015

Description
  • CMKLR1 is a G protein-coupled receptor expressed by epithelial, immune, and neuronal cell types. When activated by the endogenous peptide ligand chemerin, CMKLR1 triggers a decrease in intracellular cAMP levels via coupling with the inhibitory G protein Gαi. The physiological implications of CMKLR1 activation remain unclear. We previously outlined the development of a soluble proteolysis-resistant... read more
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