| Description |
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Background: Human and feline head and neck squamous cell carcinoma
(HNSCC) share histology, certain molecular features, as well as locally aggressive
and highly recurrent clinical behavior. In human HNSCC, the presence of significant
hypoxia within these tumors is considered an important factor in the development of a
more aggressive ... read morephenotype and poor response to therapy. We hypothesized that feline
head and neck tumors, particularly HNSCC, would exhibit hypoxia and that
64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) positron emission
tomography/computed tomography (PET/CT) would permit detection of intratumoral
hypoxia.
Keywords: Hypoxia, Head and neck cancer, Feline, 64Cu-ATSM PET/CT, O2
probe, Pimonidazole.
Springer Open.read less
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This object is in collection
| Citation |
- Ballegeer, Elizabeth, Nicole J. Madrill, Kevin L. Berger,
Dalen W. Agnew, and Elizabeth A. McNiel. "Evaluation of hypoxia in a feline model of
head and neck cancer using 64Cu-ATSM positron emission tomography/computed
tomography." BMC Cancer 13, no. 1 (12, 2013): 1-11.
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