Inhibition of Human Cytochromes P450 in vitro by Ritonavir and Cobicistat.

Hossain, Md Amin.


  • Abstract: Like ritonavir, cobicistat is also a potent inhibitor of cytochrome P450 3A enzymes, including subtype CYP3A4. Both of them have the ability to inhibit liver enzymes that metabolize other medications used to treat HIV, like atazanavir, darunavir and elvitegravir. Ritonavir and cobocistat have been using in highly active antiretroviral therapy (HAART) combination for boosting activity tha... read more
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