Roles of Sirtuin 1 Activity and Tomato Carotenoids in the Development of Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma

Cheng, Junrui.


  • Abstract: The prevalence of non-alcoholic fatty liver disease (NAFLD) is positively associated with the obesity epidemic and the risks for hepatocellular carcinoma (HCC), which is the second most cause of cancer mortality worldwide. Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that has emerged as a key metabolic sensor that links environmental signals to metabolic homeostasis, NAFLD, and to m... read more
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