3α-hydroxy-5α-pregnan-20-one: Alcohol Consumption and Anxiety in GABAA α2 knock-in C57Bl/6 Mice

Gunner, Georgia

2012

Description
  • Allopregnanolone has demonstrated anxiolytic and anticonvulsant properties via a GABAergic mechanism of action similar to that of benzodiazepines. Intermittent exposure to ethanol has produced high levels of alcohol consumption in the C57Bl/6 mice strain (Hwa et al., 2011). Withdrawal from alcohol produces anxiogenic effects in many species. A possible synergist action for ethanol and the endogeno... read more
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3b591m615
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tufts:UA005.006.151.00001
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