Intracellular Delivery of CRISPR/Cas9 and Donor Template via Lipid-like Nanoparticles for Gene Editing

Tian, Zhen.


  • CRISPR/Cas9 ribonucleoprotein (RNP) complexes offer a transient way of precise genome editing via homology-directed repair (HDR) with minimal potential off-target effect. However, intracellular delivery of RNP and donor templates remains challenging. This thesis reports a delivery vehicle based on cationic lipidoid nanoparticles (LNP) that can simultaneously deliver Cas9 RNP and a repair ... read more
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